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  • Title: Increased erythrocyte lipid peroxidation in hereditary xerocytosis.
    Author: Harm W, Fortier NL, Lutz HU, Fairbanks G, Snyder LM.
    Journal: Clin Chim Acta; 1979 Dec 03; 99(2):121-8. PubMed ID: 509735.
    Abstract:
    Xerocytosis is a chronic hemolytic anemia with abnormal membrane function manifested by an increase in passive potassium permeability. Xerocytes demonstrate a greater susceptibility to hydrogen peroxide manifested by the production of malondialdehyde (MDA). Xerocyte membrane phospholipid and fatty acid analysis is normal except for a slight increase in phosphatidyl choline, a commensurate decrease in sphingomyelin, as well as a decrease in linoleic acid. Metabolism and glutathione stability are normal as well as plasma vitamin E levels in patients with xerocytosis. The increased susceptibility to oxidant stress is exaggerated in the "older aged" xerocyte population and correlated well with decreased intracellular potassium concentration.
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