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  • Title: Pharmacokinetics of levonorgestrel in Indian women belonging to low socio-economic group.
    Author: Nair KM, Sivakumar B, Prema K, Rao BS.
    Journal: Contraception; 1979 Sep; 20(3):303-17. PubMed ID: 509957.
    Abstract:
    This study attempted to evaluate the effect of nutritional factors on the disposition of levonorgestrel (LN), as administered in a combination oral pill. Plasma samples from 11 low socioeconomic women were measured by radioimmunoassay after oral doses of 2 types of combination oral formulations, Primovlar-30 (500 mcg of LN and 30 mcg of ethinyl estradiol) and WHO-LNB (150 mcg of LN and 50 mcg of ethinyl estradiol). The following data suggest that nutritional status as reflected by anthropometry can modify the disposition of LN in women. With both preparations, plasma levels of LN reached a peak from 1-2 hours after administration and ranged from 4.6-16.2 ng/ml with Primovlar-30 and 2.8-14.4 ng/ml with LNB. The amount of LN in circulation at 48 hours was found to be more than .5 ng/ml. A triphasic decline in plasma levels of the steroid was established. Pharmacokinetic parameters calculated by graphical and regression analyses showed that the elimination half-life of the LN had a positive correlation and the peak plasma concentration a negative correlation with the 2 anthropometric indexes: weight/height sq. times 100 and skin-fold at triceps.
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