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  • Title: Possible etiology of schizophrenia: progressive damage to the noradrenergic reward system by 6-hydroxydopamine.
    Author: Stein L, Wise CD.
    Journal: Science; 1971 Mar 12; 171(3975):1032-6. PubMed ID: 5100789.
    Abstract:
    Single or repeated intraventricular injections of 6-hydroxydopamine caused marked and long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The behavioral deficits, as well as the depletion of brain norepinephrine induced by 6-hydroxydopamine, were prevented by prior treatment with chlorpromazine. Episodic or continuous formation of endogenous 6-hydroxydopamine in man as a result of a genetically determined enzymatic error could selectively damage the binding capacity and, eventually, the structural integrity of the noradrenergic reward mechanism. Such damage might cause the fundamental symptoms and long-term downhill course of schizophrenia.
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