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  • Title: Mechanisms of target cell destruction by alloimmune peritoneal macrophages. II. Release of a specific cytotoxin from interacting cells.
    Author: McIvor KL, Weiser RS.
    Journal: Immunology; 1971 Mar; 20(3):315-22. PubMed ID: 5102519.
    Abstract:
    A heat-labile cytotoxin was released into the culture medium during the first 2 hours of interaction between alloimmune mouse macrophages and specific target cells. This cytotoxin has been designated specific macrophage cytotoxin (SMC). The observation that SMC is only released when immune macrophages interact with specific target cells suggests that specificity depends on transplantation antigens. Target cell killing begins about 2 hours after exposure to SMC. Trypsin treatment of immune macrophages, which abolishes their capacity to adhere to and destroy monolayers of specific target cells, decreases the amount of SMC released into the culture medium.
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