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  • Title: [Prostaglandins and their role in the physiology of reproduction].
    Author: Husson JF.
    Journal: Gynecol Obstet (Paris); 1971; 70(3):361-8. PubMed ID: 5112630.
    Abstract:
    PGs (protsglandins), discovered in 1930s, are fatty unsaturated acids with 20 carbon atoms. There are 4 main groups, i.e. types A, B, E, and F, each containing different components. PGs have been identified in a great number of human and animal tissues; their activity is exercised on the majority of tissues and in different ways in humans and in animals. The most evident effects of PGs take place in reproductive physiology. PGs inhibit the contractility of the nonpregnant uterus in vitro, but augment the contractility in vivo. On the pregnant uterus, in vivo or in vitro, PGs cause an increase in tonus and the apparition of contractions. Thus, PGs appear to be particularly indicated in induction of therapeutic abortion and of labor, with different results according to dosage and mode of administration. The human sperm has been found to be very rich in PGs, and sterile men have apparently lower levels of PGs than fertile ones. It has also been demonstrated on laboratory animals that PGs may retard or inhibit the migration of the fertilized egg through the tubes, thus making nidation impossible.
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