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  • Title: Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis.
    Author: Aharonov A, Abramsky O, Tarrab-Hazdai R, Fuchs S.
    Journal: Lancet; 1975 Aug 23; 2(7930):340-2. PubMed ID: 51144.
    Abstract:
    Sera from patients with myasthenia gravis (M.G.) were studied by the quantitative micro-scale complement-fixation assay for the presence of humoral antibodies against acetylcholine receptor (AChR). The purified receptor was extracted from the electrogenic tissue of the electric ray, Torpedo californica. A significant difference in the antibody titres was observed between myasthenic and non-myasthenic patients. Out of fifteen patients with myasthenia gravis, at least 12 (80%) had antibodies against AChR. Only one case out of twenty-four controls had an indication of anti-receptor antibodies. In view of observations on the role of AChR as the autoantigen in myasthenia gravis, such antibodies may have significance in producing the neuro-muscular block characteristic of the disease.
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