These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Calculated deposition of inhaled particles in the airway generations of normal subjects.
    Author: Gerrity TR, Lee PS, Hass FJ, Marinelli A, Werner P, Lourenço RV.
    Journal: J Appl Physiol Respir Environ Exerc Physiol; 1979 Oct; 47(4):867-73. PubMed ID: 511695.
    Abstract:
    Detailed regional deposition of inhaled particles in the human lung is calculated for individual airway generations. The calculations are based on Landahl's deposition model as applied to the morphometric lung model of Weibel. We consider primarily deposition patterns of iron oxide particles with diameters ranging between 1 and 10 micrometers, but we also calculate patterns of deposition for bis(2-ethylhexyl) sebacate particles with diameters as small as 0.2 micrometers. We obtain good agreement between predicted values and observed values for alveolar retention of inhaled iron oxide particles with 64 and 20% of total deposition predicted to occur in nonciliated airways for 2- and 5-micrometer particles, respectively. This is compared with 48 +/- 9 and 27 +/- 10% for the measured values. Calculated values for total lung deposition of small bis(2-ethylhexyl) sebacate particles agree well with experimental data. The calculations show a minimum in deposition occurring for particle diameters of 0.5 micrometers, which is in agreement with observations. A calculation of surface concentration of deposited 7.9-micrometer aerodynamic particles reveals a very large concentration occurring at airway generation four. This observation is considered in light of observations that bronchial carcinomas occur in this vicinity of the lung.
    [Abstract] [Full Text] [Related] [New Search]