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  • Title: Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat.
    Author: Díaz JL, Huttunen MO.
    Journal: Science; 1971 Oct 01; 174(4004):62-4. PubMed ID: 5120868.
    Abstract:
    Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.
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