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  • Title: Pituitary adenomas. Clinico-morphologic correlations.
    Author: Landolt AM.
    Journal: J Histochem Cytochem; 1979 Oct; 27(10):1395-7. PubMed ID: 512326.
    Abstract:
    Immunohistochemistry and electron microscopy allow new insights into the biology and natural history of the proliferative processes of the hypophysis. Hyperplasia can be diffuse or focal. Its function and/or growth are controlled by hypothalamic factors. Hyperplasia may precede the formation of an adenoma. Function and/or growth of adenomas is partially or completely independent of hypothalamic regulation. Adenomas are divided according to their functional activity into an endocrine active and inactive group. A further subdivision is made according to the secreted hormone. Inactive adenomas may have lost the ability to produce hormones, may secrete hormones at a very low rate, or may secrete abnormal substances.
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