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  • Title: Comparative nephrotoxicity of aspirin and phenacetin derivatives.
    Author: Calder IC, Funder CC, Green CR, Ham KN, Tange JD.
    Journal: Br Med J; 1971 Nov 27; 4(5786):518-21. PubMed ID: 5128205.
    Abstract:
    Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection. Phenacetin derivatives tended to produce more severe renal damage and to be nephrotoxic in smaller doses than aspirin derivatives. With the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.
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