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  • Title: Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin.
    Author: Baldwin GS, Carnegie PR.
    Journal: Biochem J; 1971 Jun; 123(1):69-74. PubMed ID: 5128665.
    Abstract:
    Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, omega-NN'-dimethylarginine and omega-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed.
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