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  • Title: Stability-indicating assay of acetaminophen in an effervescent tablet by ion-pair high-performance liquid chromatography.
    Author: Sena FJ, Piechocki JT, Li KL.
    Journal: J Pharm Sci; 1979 Nov; 68(11):1465-6. PubMed ID: 512905.
    Abstract:
    A stability-indicating analytical method is described for determining acetaminophen and its degradation product, p-aminophenol, in an affervescent tablet. Tablets assayed by ion-pair high-performance reversed-phase liquid partition chromatography required no sample cleanup. The method applied to tablets containing 325 mg of acetaminophen yielded an average recovery of 99.6% with a relative standard deviation of 0.70% (n = 10). As little as 0.005% p-aminophenol could be detected.
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