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  • Title: The effect of prolonged pancreatic secretion on blood acid-base balance in the conscious dog.
    Author: Fawcett AN, Newman CA.
    Journal: Gut; 1971 Nov; 12(11):918-21. PubMed ID: 5132224.
    Abstract:
    Prolonged near maximal pancreatic secretion in conscious dogs has been found to result in a metabolic acidosis. This is mild and is accompanied by respiratory and other forms of compensation. Measurements of blood bicarbonate or base-excess changes cannot be used to estimate pancreatic bicarbonate output. The acidosis caused by pancreatic secretion cannot explain the changes in bicarbonate concentration seen in pancreatic juice during prolonged secretion.
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