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  • Title: The absorption, distribution and excretion of 3 H-chlorambucil in rats bearing the Yoshida ascites sarcoma.
    Author: Hill BT, Riches PG.
    Journal: Br J Cancer; 1971 Dec; 25(4):831-7. PubMed ID: 5144543.
    Abstract:
    The distribution of (3)H-chlorambucil following its administration by subcutaneous injection to Yoshida ascites tumour-bearing rats has been examined, in an attempt to elucidate the metabolic fate and mode of action of this drug.Drug uptake into the body tissue was rapid, with a high level of radioactivity being associated with the plasma and ascitic fluid during the initial 6-hour period after treatment. Previous studies in vitro had shown that chlorambucil-resistant cells accumulated less drug than their sensitive counterparts: this discrepancy was also observed after in vivo drug treatment and was reflected in the two-fold difference in extent of binding of tritium to DNA, RNA and protein isolated from the 2 cell strains. These results might in part explain the observed difference in metabolism of chlorambucil by the resistant and sensitive strain of Yoshida ascites sarcoma cells.
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