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  • Title: In vitro lymphocyte responses and skin test reactivity following BCG vaccination.
    Author: Thomas JW, Clements D, Grzybowski S.
    Journal: Clin Exp Immunol; 1971 Nov; 9(5):611-23. PubMed ID: 5145430.
    Abstract:
    In a study of student nurses given BCG we have shown that there is no correlation between skin test response and the lymphocyte transformation response to PPD tuberculin (CT68) and PPD-B as measured by [3H]thymidine uptake. This suggests that one is measuring two unrelated immunological events. The vaccine dosage was found to influence the cutaneous response that developed without effecting the lymphocyte transformation response. Significant correlation was found between skin test reactions to PPD-S and PPD-B, PPD-S and PPD-G, PPD-B and PPD-G. Both in vivo and in vitro reactions to PPD-CT68 and -S were significantly greater than to PPD-B. The in vitro correlation of response to PPD-CT68 and PPD-B were excellent. A rather poor, although significant, correlation exists between IgM levels and the PHA in vitro response, and a rather better correlation between the in vitro responses to PPD-CT68 and PHA. There was no correlation between the peripheral blood absolute lymphocyte count and any of the in vivo or in vitro reactions to PPD or PHA.
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