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  • Title: The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage mu2.
    Author: Shooter KV, Edwards PA, Lawley PD.
    Journal: Biochem J; 1971 Dec; 125(3):829-40. PubMed ID: 5145907.
    Abstract:
    Bacteriophage mu2 is inactivated by both mono- and di-functional sulphur mustards at relatively low extents of alkylation. No degradation of alkylated RNA was detected. Cross-linking of RNA to protein was observed with the difunctional agent, but this reaction was only a minor contribution to the inactivation. Analyses of the reaction products in bacteriophage RNA showed that, at the mean lethal doses, more than one mono-alkylation of guanine had occurred but the sum total of other types of RNA alkylation was close to a single event. The results therefore suggest that inactivation results from the mono-alkylation of adenine or cytosine. In experiments with the difunctional agent cross-linking of RNA bases or of RNA to protein also prevented replication, the existence of these reactions accounting for the greater sensitivity of the bacteriophage to this agent.
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