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  • Title: Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.
    Author: Mujtaba Q, Burrow GN.
    Journal: Obstet Gynecol; 1975 Sep; 46(3):282-6. PubMed ID: 51489.
    Abstract:
    Twenty-one women were studied who had received propylthiouracil or methimazole during 26 pregnancies. Four of the infants had a goiter at birth, and 3 of these had neonatal thyrotoxicosis. In 2 children neonatal thyrotoxicosis was not evident at birth because of maternal antithyroid therapy. Five children had congenital defects. Two mothers were responsible for 4 of the children with abnormalities, and both mothers had been treated with thiourea drugs for long periods, ranging from 7 to 11 years. The majority of children who are exposed to these drugs in utero appear to have no subsequent ill effects. However, prolonged therapy with these agents may be undesirable.
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