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  • Title: [Action of testosterone on the genital tract of the male rat treated with stilbestrol].
    Author: Mayer G.
    Journal: Ann Endocrinol (Paris); 1971; 32(6):725-41. PubMed ID: 5151011.
    Abstract:
    The effects of 100 mg tablets of testosterone or stilbestrol or both implanted sc in 21-day-old or mature rats were recorded on growth, testis weight, and histology, accessory glands, and lactation. Stilbestrol implanted in adult rats caused involution of scrotum, testicles, seminiferous tubules, spermatogenesis, and the interstitial gland. Testosterone and stilbestrol implanted simultaneously in adults permitted normal testis weight and seminiferous tubules but caused atrophy of the interstitial gland, but after 4 months the testis tubules varied widely within and between individuals. In prepubertal rats, stilbestrol caused involution of the testis seminal vesicles, interstitial glands, and induced lactation. Simultaneous treatments allowed some testicular development, but the Leydig cells were still involuted. When testosterone was implanted 15 days after stilbestrol, testis morphology and weight were intermediate in adults, but further de veloped in prepubertal rats than in the previous experiments. Stilbestrol caused profound involution of male accessory glands, and lactation. Simultaneous hormones caused hypertrophy of the accessory glands and lactation. The relults were interpreted in terms of inhibition of luteinizing hormones and follicle stimulating hormone secretion and enhanced prolactin secretion.
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