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  • Title: Problems of diagnosis of disseminated intravascular coagulation (DIC).
    Author: Bowie EJ, Owen CA.
    Journal: Southeast Asian J Trop Med Public Health; 1979 Sep; 10(3):325-7. PubMed ID: 515796.
    Abstract:
    Acute generalized intravascular coagulation is regularly associated with fibrinolysis. Evidence of the clotting process includes thrombocytopenia, hypofibrinogenemia, prolongation of the prothrombin time (deficiency of factor V and fibrinogen) and of the partial thromboplastin time (factor VIII is also deficient). Evidence of fibrinolysis is elevation of fibrinolytic split products (FSP or FDP). A positive protamine gel results from both coagulation and fibrinolysis.
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