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  • Title: The effects of maturation and prenatal hypoxia on the pulmonary and body fluid content and alveolar lining layer of foetal rabbits, and their relevance to the respiratory distress syndrome.
    Author: DeSa DJ.
    Journal: Br J Exp Pathol; 1969 Feb; 50(1):42-50. PubMed ID: 5191188.
    Abstract:
    Pulmonary fluid content, body fluid content and fluorescent alveolar lining layers have been studied in maturing rabbit foetuses and it has been shown that there is a steady decrease in the proportion of pulmonary and body fluid as the foetus matures. It is argued that these changes are related to alterations of capillary permeability as the foetus matures. It has been shown that alveolar lining layers can be demonstrated with increasing frequency as the foetus matures. It is suggested that any functional deficiency of surfactant production in immature foetuses can only be exaggerated by increased pulmonary capillary permeability. Studies of prenatally hypoxic 28-29 and 30-31 (term) day-old foetuses have shown that these foetuses have increased pulmonary and body fluid content and a decreased frequency of demonstrable alveolar lining layers when compared to control animals. It is argued that all these changes can be explained on the basis of increased capillary permeability. The relationship of these findings to the pathogenesis of the respiratory distress syndrome of the newly born is discussed.
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