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  • Title: Effect of isoproterenol on the isolated pregnant rat myometrium.
    Author: Meisheri KD, McNeill JH, Marshall JM.
    Journal: Eur J Pharmacol; 1979 Nov 23; 60(1):1-6. PubMed ID: 520410.
    Abstract:
    In pregnant rat myometrium, isoproterenol (10(-8) M) inhibited spontaneous contractions without causing hyperpolarization. Isoproterenol (10(-6) M) relaxed the depolarized muscle without affecting the membrane potential. The presence of 80 mM Na+ did not affect the degree of high-K+ depolarization. It was also without any influence on the effects of isoproterenol on the depolarized uterus. The results are consistent with the concept that hyperpolarization is not a prerequisite for beta-adrenoceptor induced relaxation of uterine smooth muscle.
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