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  • Title: High pressure liquid chromatographic determination of the rodenticide brodifacoum in rat tissue.
    Author: Koubek KG, Ussary JP, Haulsee RE.
    Journal: J Assoc Off Anal Chem; 1979 Nov; 62(6):1297-301. PubMed ID: 521415.
    Abstract:
    An HPLC method was developed to determine residues of individual isomers of brodifacoum (3-[3-4'-bromo[1,1'-biphenyl]-4-yl)-1, 2, 3, 4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one) in rat tissue. The compound was extracted twice with 10% methanol in chloroform, filtered, and cleaned up by using automated gel permeation chromatography. A final cleanup on a silica gel SEP-PAK was added to protect the analytical column from irreversible adsorption and to reduce analysis time. The analysis was done on a microPorasil column; a UV detector was used for quantitation. Recoveries of brodifacoum added to rat tissue in concentrations of 0.12-5.0 ppm were greater than 90%.
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