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  • Title: Plant anticancer agents. IX. Constituents of Hyptis tomentosa.
    Author: Kingston DG, Rao MM, Zucker WV.
    Journal: J Nat Prod; 1979; 42(5):496-9. PubMed ID: 521819.
    Abstract:
    The twigs, leaves, and flowers of Hyptis tomentosa were found to owe their major cytotoxic activity to the presence of desoxypodophyllotoxin (4), but the two weakly cytotoxic flavones 5-hydroxy-4',6,7,8-tetramethoxy flavone (3) and 5-hydroxy-4',3,6,7,8-pentamethoxy flavone (2) also contributed to the total cytotoxicity of the crude extracts. The flavones eupatorin (6) and 5-hydroxy-3',4',6,7-tetramethoxy flavone (5) were isolated as inactive constituents, together with the lignan sesamin (1).
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