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  • Title: Is the cancer process caused by deletion of one or more differentiation genes normally activated by steroid hormones?
    Author: Money-Kyrle AF.
    Journal: Med Hypotheses; 1979 Sep; 5(9):987-94. PubMed ID: 522710.
    Abstract:
    The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens cause the deletion of genes necessary for the production of a substance required for differentiation of the cell and activated by a steroid hormone possibly a corticosteroid. 2. Such genes could include genes for production of: glutamine transaminase, glutamine synthetase, genes involving vitamin A metabolism. 3. Deletion of any of these genes could cause the cell to remain in an undifferentiated and replicating state.
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