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  • Title: Palate morphogenesis. III. Changes in cell shape and orientation during shelf elevation.
    Author: Babiarz BS, Wee EL, Zimmerman EF.
    Journal: Teratology; 1979 Oct; 20(2):249-78. PubMed ID: 524299.
    Abstract:
    The process of palate shelf elevation has been analyzed by light microscopy in mouse embryos cultured in vitro. The observations presented correlate changes in cell shape and orientation in the palate with the morphogenetic movement of the shelf. These studies suggest that in addition to any physical-chemical force elevating the shelf an active contraction of specific palate cells could also aid the process. Contribution to elevation could be derived from masses of contracting cells from the previously described non-muscle contractile systems in posterior (region 2) and mid-anterior (region 3) palate as well as other peripheral mesenchymal cells. Finally, elongation and contraction of the tongue side epithelial cells may also play a role in palate elevation.
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