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  • Title: [Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
    Author: Buriot D, Prieur AM, Lebranchu Y, Messerschmitt J, Griscelli C.
    Journal: Arch Fr Pediatr; 1979 Jun; 36(6):592-8. PubMed ID: 526114.
    Abstract:
    Three children out of a total of 40 who had been treated with chlorambucil for juvenile rheumatoid arthritis developed acute leukaemia. No malignancy was detected in 160 patients in those treated with steroids and/or other anti-inflammatory drugs. Chlorambucil may have induced the malignancies and its use should be avoided in rheumatoid arthritis.
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