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  • Title: Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position.
    Author: Blomquist AT, Rich DH, Carlson BA, Allen GA, Hruby VJ, Takashima H, Nangeroni LL, Glose P, Du Vigneaud V.
    Journal: Proc Natl Acad Sci U S A; 1969 Sep; 64(1):263-6. PubMed ID: 5263009.
    Abstract:
    This paper describes the synthesis and biological activity of [5-L-asparagine-alpha,beta,beta-d(3)]-deamino-oxytocin. The model peptide S-benzyl-beta-mercaptopropionyl-L- asparaginyl-alpha,beta,beta-d(3)-glycinamide was also prepared to observe the effect of the conditions of peptide synthesis on the deuterium content. It was found that normal synthetic procedures could be used without a significant loss in the deuterium content.The [5-L-asparagine-alpha,beta,beta-d(3)]-deamino-oxytocin had, within experimental error, the same avian vasodepressor and oxytocic activities as deamino-oxytocin itself.
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