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  • Title: Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).
    Author: Richardson K, Brammer KW, Jevons S, Plews RM, Wright JR.
    Journal: J Antibiot (Tokyo); 1979 Oct; 32(10):973-7. PubMed ID: 528375.
    Abstract:
    1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.
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