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  • Title: The longitudinal intraluminal concentration gradient in the perfused rat jejunum and the appropriate mean concentration for calculation of the absorption rate.
    Author: Winne D, Markgraf I.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1979 Nov; 309(3):271-9. PubMed ID: 530306.
    Abstract:
    In anaesthetized rats, jejunal segments 30 cm in length were perfused (rates:0.1, 0.2,0.5 ml/min) with solutions containing antipyrine, salicylic acid, urea, L-lysine, L- and D-phenylalanine. The intraluminal concentration was determined approx. 10, 20, and 30 cm from the inflow cannula. The intraluminal concentration gradients were almost exponential and corresponded to the gradient predicted for a laminar flow through a solute-permeable circular tube. This gradient has a slightly greater curvature than the exponential one. Theoretical considerations showed that the logarithmic mean (Co-Cz)/ln(Co/Cz) of the in- and outflow concentration is the best average value for application in non-integrated absorption equations. This is also valid for the temporal concentration gradient after single administration of a substance into an intestinal segment.
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