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  • Title: Haemagglutination-inhibiting antibody response to and efficacy of inactivated Hong Kong influenza vaccine.
    Author: Sonoguchi T.
    Journal: Bull World Health Organ; 1969; 41(3):517-23. PubMed ID: 5309466.
    Abstract:
    In a field study involving some 3000 soldiers in Japan, various doses from 0.2 ml to 1.0 ml of formol-killed monovalent Hong Kong influenza vaccine were administered. Before vaccination 92% of the subjects had haemagglutination-inhibiting antibody titres of <1:16; one month after vaccination, only from 1% to 57% (depending on the dose and the soldiers' camp involved) had so low an antibody level. In one vaccinated camp an epidemic of Hong Kong influenza broke out in January-March 1969. In a unit in which 80% of the men had been vaccinated, there was an infection rate of 16% among the vaccinated, of 26% among the unvaccinated living in the same barracks and of 63% among the unvaccinated living in separate barracks; these figures suggest that vaccination of at least 80% of a population group will afford some protection to the unvaccinated remainder of the group against an epidemic of influenza provided the vaccinated and the unvaccinated are living in close association.
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