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  • Title: Effect of progesterone on collagen breakdown and tissue collagenolytic activity in the involuting rat uterus.
    Author: Halme J, Woessner JF.
    Journal: J Endocrinol; 1975 Sep; 66(3):357-62. PubMed ID: 53256.
    Abstract:
    Progestational agents were studied for their effects on collagenolytic activity and loss of collagen and wet weight from the involuting post-partum rat uterus. Administration of very large doses of progesterone (80-150 mg/day) significantly retarded uterine involution and loss of collagen. This was accompanied by a significant reduction in uterine collagenolytic activity. By 72 h post partum, uteri of rats treated with 150 mg progesterone/day had wet weights 30% above, collagen 85% above, and collagenolytic activity 45% below, those of the control uteri. Similar effects were produced by 17alpha-acetoxy-6alpha-methylprogesterone at the same dosage levels. However, the progestational agent 6-chloro-17alpha-acetoxypregna-4,6-diene-3,20-dione acetate had no effect in this system.
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