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  • Title: Successful fetal liver transplantation in a child with severe combined immunodeficiency.
    Author: Keightley RG, Lawton AR, Cooper MD, Yunis EJ.
    Journal: Lancet; 1975 Nov 01; 2(7940):850-3. PubMed ID: 53333.
    Abstract:
    Following transplantation with allogeneic fetal liver, a boy with a severe combined immunodeficiency and adenosine-deaminase (A.D.A.) deficiency developed immunocompetent T and B cells in an orderly manner. Engraftment was indicated by appearance of A.D.A. activity and donor-lymphocyte and red-cell antigens. The child remained free of major infections until one year later when he developed an ultimately fatal nephrotic syndrome associated with immune-complex glomerulonephritis.
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