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  • Title: Early antibody response in mice to either infection or immunization with Salmonella typhimurium.
    Author: Kenny K, Herzberg M.
    Journal: J Bacteriol; 1967 Mar; 93(3):773-8. PubMed ID: 5337833.
    Abstract:
    After immunization with either live or heat-killed Salmonella typhimurium, mice responded with an extremely rapid production of bactericidal antibody which was correlated with the appearance of immunity to a heavy challenge dose (100 ld(50)) of the virulent bacteria. Inactivation of sera with mercaptoethanol along with Sephadex fractionation indicated that the observed bactericidal activity was associated with a macroglobulin which was completely mercaptoethanol-sensitive. The unexpected finding, that a heat-killed vaccine gave excellent protection from a challenge dose which killed all unimmunized control mice, seriously challenges the theory attributing immunity against typhoid infection entirely to a cellular host factor produced only in response to a live vaccine.
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