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  • Title: Effects of carbon disulphide on the liver of rats.
    Author: Bond EJ, Butler WH, De Matteis F, Barnes JM.
    Journal: Br J Ind Med; 1969 Oct; 26(4):335-7. PubMed ID: 5346831.
    Abstract:
    Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968).Brit. J. industr. Med.,26, 335-337. Effects of carbon disulphide on the liver of rats. Normal rats surviving a single oral dose of carbon disulphide (CS2) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS2, the LD50 does not change but liver necrosis is produced.
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