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  • Title: Histamine formation in rat gastric mucosa and lung after injecting reserpine or adrenaline.
    Author: Rosengren E, Svensson SE.
    Journal: Br J Pharmacol; 1969 Nov; 37(3):659-65. PubMed ID: 5348468.
    Abstract:
    1. In rats the effect of reserpine, adrenaline and gastrin on the histamine forming capacity (HFC) of gastric mucosa and lung was examined.2. Intraperitoneal reserpine as well as subcutaneous adrenaline produced a great increase in HFC of gastric mucosa but a great decrease in HFC of lung. After reserpine the HFC of lung was almost abolished.3. As the HFC changes produced by reserpine occurred also after demedullation of the suprarenals--the changes in the mucosa were in fact accentuated--release of the medullary hormones by the reserpine does not account for these changes.4. Subcutaneous gastrin caused a great increase in HFC of the gastric mucosa but did not affect the HFC in lung.5. The possible role of release of gastrin and corticosteroids for the reserpine-induced HFC changes is discussed because it is known that reserpine releases gastrin and corticosteroids and that cortisone produces HFC changes in gastric mucosa and lung.
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