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  • Title: Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets.
    Author: Sneddon JM.
    Journal: Br J Pharmacol; 1969 Nov; 37(3):680-8. PubMed ID: 5348470.
    Abstract:
    1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.
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