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  • Title: Identification of cholecystokinin-secreting cells.
    Author: Polak JM, Bloom SR, Rayford PL, Pearse AG, Buchan AM, Thompson JC.
    Journal: Lancet; 1975 Nov 22; 2(7943):1016-8. PubMed ID: 53500.
    Abstract:
    Cholecystokinin (C.C.K.)-producing cells were identified in the mucosa of the upper small intestine in man and other mammals by immunocytochemical techniques and electron microscopy on semi-thin and serial thin sections. Ultrastructural studies suggested that the C.C.K.-producing cells resemble I cells of the modified Wiesbaden classification. The combination of these techniques provides a simple and reliable method of identifying C.C.K. cells in human biopsy material and will be useful in the investigation and diagnosis of gut endocrine dysfunctions.
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