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  • Title: Increased plasma activities of N-acetyl-beta-D-glucosaminidase isoenzymes in human diabetes mellitus.
    Author: Poon PY, Dornan TL, Ellis RB, Turner RC.
    Journal: Clin Endocrinol (Oxf); 1979 Dec; 11(6):625-30. PubMed ID: 535168.
    Abstract:
    Plasma N-acetyl-beta-D-glucosaminidase activities are raised in maturity-onset insulin-dependent diabetic patients. Continuous gradient DEAE-cellulose column chromatography and assay of heat-stable enzyme activity both show that the activities of all isoenzymes are equally increased rather than a previously described increase of specific isoenzymes. Plasma enzyme activities are similarly increased in patients with and without diabetic retinopathy, and correlate with simultaneous plasma glucose concentrations.
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