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  • Title: Hormone serum levels and hormone receptor contents of endometria in women with normal menstrual cycles and patients bearing endometrial carcinoma.
    Author: Spona J, Ulm R, Bieglmayer C, Husslein P.
    Journal: Gynecol Obstet Invest; 1979; 10(2-3):71-80. PubMed ID: 535775.
    Abstract:
    Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (HPRL), 17 beta-estradiol (E2) and progesterone (P) were estimated in 46 subjects with normal menstrual cycles in whom hysterectomies were performed. Estrogen (ER) and progesterone receptor (PgR) levels in endometrial samples of these patients were estimated, and histological dating of the cycle day was carried out. Similarly, hormone serum levels and ER as well as PgR were estimated in 17 patients with endometrial carcinoma. No correlation between LH, FSH, HPRL and ER as well as PgR was noted in the normal subjects. Correlation between P and ER was observed in this group. Parallel variations between E2 and PgR were recorded in the normal females. In the carcinoma group no correlations between hormone serum levels and receptor contents were found, but ER and PgR correlated with each other. Receptor levels was highest in the well-differentiated group of endometrial carcinoma. The present experiments provide a rationale for progestagen therapy of carcinoma of the endometrium. 17 subjects with endometrial carcinoma, who underwent therapeutic hysterectomy, had their serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, (HPRL), 17-beta-estradiol (E2), and progesterone (P) estimated to study whether there were any correlations between hormone serum levels and contents of hormone receptors in females with endometrial carcinoma. Additionally, these parameters were also estimated in 46 normal cycling women undergoing hysterectomies for other indications. Receptor levels (both progesteron, PgR, and estrogen ER) of the tissue samples were also assayed, all in an effort to provide a rationale for hormone therapy of endometrial carcinoma. The tissue samples from normal women were histologically dated as to cycle day the procedure was carried out. In all there were no correlations between LH, FSH, HPRL, and ER or PgR in normal subjects. However, correlation between P and ER was observed in this group of endometrial cancer subjects. There were parallel variations in normal women between E2 and PgR. In the carcinoma group, no correlations between hormone serum levels and receptor contents were found, but ER and PgR correlated with each other. Receptor levels were highest in the well-differentiated group of endometrial carcinoma. These experiments give impetus to use of progestagen therapy for endometrial carcinoma.
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