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  • Title: Interaction between theophylline and oestrogen in the rat uterus.
    Author: Steinsapir J, Rojas AM, Fernández A, Alburquerque M, León S, Bustón P, Pacheco R, Munizaga A, Habash L, Ojeda JM, Tchernitchin A.
    Journal: J Endocrinol; 1979 Dec; 83(3):277-84. PubMed ID: 536665.
    Abstract:
    Theophylline alone or in the presence of 0.001, 0.01, 0.1 or 1 microgram oestradiol-17 beta/100 g body wt increase uterine RNA and protein content 6 h after administration. Uterine oedema induced by physiological doses of oestradiol-17 beta was increased further in the presence of theophylline. Theophylline decreased the number of eosinophils in the blood and concurrently decreased oestrogen-induced uterine oesinophilia at doses of 0.01, 0.1, 1, 10 or 30 micrograms oestradiol-17 beta/100 g body wt. Oestrogen binding by uterine eosinophils in vitro increased in the presence of theophylline. This effect of theophylline could explain the increase of oestrogen-induced uterine oedema in vivo.
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