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  • Title: Studies on the metabolism and toxicity of dinitrotoluenes. Toxicological study of 2,4-dinitrotoluene (2, 4-DNT) in rats in long term feeding.
    Author: Kozuka H, Mori M, Naruse Y.
    Journal: J Toxicol Sci; 1979 Aug; 4(3):221-8. PubMed ID: 537127.
    Abstract:
    2, 4-Dinitrotoluene (2, 4-DNT) was incorporated at the level of 0.5% in a standard commercial diet and fed ad lib. to male rate for 6 months. Significant changes were noted in the body weight, organ weight, behavior, mortality, and biochemical analysis of blood and serum of rats ingesting 2, 4-DNT. Furthermore, it was found that the ingestion of 2, 4-DNT affected on the activities of drug metabolizing enzymes in liver microsomes.
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