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  • Title: Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.
    Author: Kraus P.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1975; 291(1):79-87. PubMed ID: 53794.
    Abstract:
    Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the alpha-HCH-residue with GSH. The other cytoplasmic alpha-HCH-dechlorinase requires no additions. The microsomes, too, contain two alpha-HC dechlorinases at least: one is stimulated by GSH, the other by NADPH.
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