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  • Title: Alteration of biliary ursodeoxycholic acid in guinea pig during early stages of cholestyramine feeding.
    Author: Li JR, Dinh DM, Kottke BA.
    Journal: Steroids; 1979; 34(6 Spec no):705-15. PubMed ID: 538776.
    Abstract:
    The effects of cholestyramine feeding on biliary ursodeoxycholic acid, fecal excretion of bile acids and neutral sterols on cholesterol 7 alpha-hydroxylase and hepatic HMG-CoA reductase were examined in the guinea pig. In the bile there was a 57% decrease in the concentration of ursodeoxycholic acid while an increase was observed in the concentration of chenodeoxycholic acid. Cholestyramine feeding for ten days resulted in a decrease in plasma cholesterol levels and an increase in both hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities. The fecal excretion of both bile acids and neutral sterols was significantly increased.
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