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  • Title: The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.
    Author: Schiffer CA, Aisner J, Schmukler M, Whitaker CL, Wolff JH.
    Journal: Transfusion; 1975; 15(5):473-5. PubMed ID: 53920.
    Abstract:
    The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucleotide and serotonin release, and platelet factor-3 availability were also unchanged after exposure to HES. It is concluded that HES has no adverse effect on cell function and appears to be a suitable adjuvant agent for blood cell component collection.
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