These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increase in local cerebral blood flow induced by circulating adrenaline: involvement of blood-brain barrier dysfunction.
    Author: Abdul-Rahman A, Dahlgren N, Johansson BB, Siesjö BK.
    Journal: Acta Physiol Scand; 1979 Nov; 107(3):227-32. PubMed ID: 539453.
    Abstract:
    The influence of intravenous infusion of adrenaline (8 micrograms.kg-1.min-1) upon local cerebral blood flow (CBF) in paralyzed and artifically ventilated rats was measured autoradiographically with 14C-iodoantipyrine as the diffusible tracer. At this dose, adrenaline invariably increased local CBF even though blood pressure was close to normal at the time of the CBF measurement. In average, local CBF increased to 400% of control. In 6 of 9 animals the increase in flow was inhomogenous with randomingly distributed areas of very high flow rates. Experiments with i.v. administration of Evans blue prior to infusion of adrenaline showed that areas of Evans blue extravasation appeared in 3 of 4 animals. Although areas of extravasation often corresponded to areas of high flow rates the former were much more circumscribed. Furthermore, very high flow rates were found in areas showing no sign of blood-brain barrier dysfunction. It is concluded that the increase in CBF was at least partly due to a pressure-mediated passage of adrenaline across the blood-brain barrier but that such a passage can occur in the absence of macroscopically visible extravasation of protein.
    [Abstract] [Full Text] [Related] [New Search]