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  • Title: A tranqlizer-anticholinergic preparation in functional gastrointestinal disorders: a double-blind evaluation.
    Author: Wayne HH.
    Journal: Calif Med; 1969 Aug; 111(2):79-83. PubMed ID: 5394587.
    Abstract:
    UNLABELLED: Chlordiazepoxide plus clidinium bromide (Librax(R)) was evaluated and compared with a placebo by means of a random sample, double-blind crossover technique in 42 patients presenting ordinary functional gastrointestinal disorders. RESULTS: * 73.9 percent excellent-to-good response to the active drug in patients receiving it before they received the placebo, compared with 44.5 percent in those who did not receive it until after the placebo period.* 58.9 percent excellent-to-good response to the active drug in patients who received it after the placebo period, as compared with 31.8 percent in those receiving the placebo last.* Overall clinical response 67.5 percent excellent-to-good with the active drug as compared with 37.5 percent with the placebo.* Excellent-to-good results in 12 follow-up patients receiving the known active drug.* Statistically significant symptomatic response in four of eight target symptoms. The tranquilizer-anticholinergic preparation used appeared to improve not only patient outlook and attitudes but to effectively relieve both the physiologic and psychic manifestations of common functional gastrointestinal disorders.
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