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  • Title: [Serum levels of alpha-2-macroglobulin, ceruloplasmin, transferrin, alpha-1-antitrypsin and complement (beta-1-C) before and following 3- and 6-day injections of D-penicillamine in man].
    Author: Cegla UH.
    Journal: Z Rheumatol; 1975; 34(9-10):301-8. PubMed ID: 53962.
    Abstract:
    UNLABELLED: The serum levels of alpha-1-antitrypsin, ceruloplasmin, transferrin, alpha-2-macroglobulin and complement (beta-1-C) were measured by the radioimmunodiffusion method of Mancini before treatment, after three days treatment with D-penicillamine (1,00 g. i. v. daily) and after treatment for 3 days with 2 x 1,00 g i. v. D-Penicillamine. The levels of alpha-2-macroglobulin, coeruloplasmin and transferrin dropped significantly after 3 days' treatment. Doubling the dosage for 3 days induced a further drop in transferrin and ceruloplasmin. The alpha-2-macroglobulin was not further influenced. The levels of alpha-1-antitrypsin and complement were not influenced by D-Penicillamine treatment. KEYWORDS: D-penicillamine, alpha-1-Antitrypsin, alpha-2-macroglobulin, transferrin, ceruloplasmin, complement (beta-1-C).
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