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  • Title: [Coagulation and fibrinolysis proteins in nephrotic syndromes in children].
    Author: Loirat C, Pillion G, Schlegel N, Douenias R, Mathieu H.
    Journal: Arch Fr Pediatr; 1979 Nov; 36(9 Suppl):LVI-LXIII. PubMed ID: 539878.
    Abstract:
    The main coagulation and fibrinolysis proteins have been studied in 22 children with nephrotic syndrome. Some anomalies such as the increase of fibrinogen and of Factors II, V, VII + X concentrations and the decrease of antithrombin III concentration could induce an hypercoagulability. Other anomalies such as the high alpha 2 macroglobulin concentration and the frequently low plasminogen concentrations could induce a decrease of the plasma fibrinolytic activity. The consequences of the low alpha 1 antitrypsin levels are probably less important. The fast alpha 2 antiplasmin levels have been found variable in the different patients. Practically, it appears that most children with plasma albumin levels less than 15-17 g/l have antithrombin III levels less than 23 mg/dl (70% of normal), which appears to result in a high risk of thrombosis (11).
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