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  • Title: A study of the effect of povidone-iodine on polymorphonuclear leucocyte chemotaxis.
    Author: Connolly JC, Gilmore OJ.
    Journal: Br J Exp Pathol; 1979 Dec; 60(6):662-6. PubMed ID: 540106.
    Abstract:
    Studies were made of the effect of povidone-iodine on polymorphonuclear leucocyte chemotaxis. Polymorphonuclear leucocytes were incubated with various concentrations of povidone-iodine and allowed to migrate across a membrane towards a chemotactic agent. Chemotactic movement was found to decrease as the concentration of povidone-iodine rose, 75 micrograms/ml completely inhibiting all movement. A concentration of 10 micrograms/ml of povidone-iodine was found actively to repel the white cells. In vivo studies in mice showed a reduction in polymorphonuclear leucocytes at wound surfaces in the presence of povidone-iodine dry powder spray.
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