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  • Title: [Changes in somatotropic and lactotropic functions of the adenohypophysis of rats with acute alloxan diabetes].
    Author: Gudoshnilov VI, Komolov IS, Plizhnikova GN, Sadovnikova NV.
    Journal: Biull Eksp Biol Med; 1979 Nov; 88(11):536-8. PubMed ID: 540138.
    Abstract:
    Increased growth hormone and prolactin contents of the rat adenohypophysis during the development of experimental diabetes were found by colorimetric studies of stained electrophoregrams. 4 to 5 days after alloxan administration the levels of somatotropic hormone (STH) and prolactin were higher in comparison to those in intact animals by 58% and 43%, respectively. Experiments on the primary cell culture using the precursor 14C-L-leucine revealed an enhanced secretion of somatotropic hormone and prolactin by cells of the rats with alloxan diabetes. A possible role of the adenohypophyseal changes in the development of experimental diabetes is discussed.
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